Developed by the Pennsylvania Railroad, the South Wayne Historic District includes 316 contributing buildings in a residential area of Wayne. The majority of the dwellings were built between 1881 and 1930, and include notable examples of Shingle Style and Colonial Revival architecture, representing the work of Will Price, Horace Trumbauer, and several other area architects.

The district reflects suburban development in the late-19th century as it was a major component of a large, planned, railroad commuter suburb called “the Wayne Estates,” complementing the northern half of the residential area which is now included in the North Wayne Historic District, and the downtown area of Wayne, which sits between the two residential districts, now the Downtown Wayne Historic District.